Metabotropic Glutamate Receptor 5 Antikörper (C-Term)

Produktnummer ABIN6658205

Produktdetails anti-Metabotropic Glutamate Receptor 5 Antikörper

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Bindungsspezifität: C-Term

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: mGluR5/1a Antibody

Kreuzreaktivität (Details): Anti-mGluR5/1a antibody is directed against GluR5/1a.

Aufreinigung: GluR5/1a antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-mGluR5/1a Antibody was produced in rabbit by repeated immunizations with synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry_Dilution: 1:500

Western_Blot_Dilution: 1:1000

Kommentare:

Anti-mGluR5/1a (Rabbit) antibody is tested for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 125 kDa monomer and 250 kDa dimer in size corresponding to mGluR5 and mGluR1 proteins in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu Metabotropic Glutamate Receptor 5

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Andere Bezeichnung: Grm5 (GRM5 Produkte)

Synonyme: GPRC1E antikoerper, MGLUR5 antikoerper, mGlu5 antikoerper, mGluR5 antikoerper, mGlur5 antikoerper, 6430542K11Rik antikoerper, AI850523 antikoerper, Glu5R antikoerper, Gprc1e antikoerper, mGluR5b antikoerper, glutamate receptor, metabotropic 5 antikoerper, glutamate metabotropic receptor 5 antikoerper, GRM5 antikoerper, Grm5 antikoerper

Hintergrund:

Synonyms: mGluR5, Metabotropic Glutamate Receptor 5/1a

Background: mGluR5/1a antibody detects GluR5/1a protein. The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse. Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity. In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus. mGluR5/1a is ideal for investigators involved neuronal circuitry and more generally in Neuroscience.

Gene Name: GRM5

Gen-ID: 24418

UniProt: P31424

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity