GABRB3 Antikörper (Cytoplasmic Loop)
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- Target Alle GABRB3 Antikörper anzeigen
- GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))
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Bindungsspezifität
- Cytoplasmic Loop
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GABRB3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Kreuzreaktivität
- Maus, Ratte (Rattus)
- Kreuzreaktivität (Details)
- Cross reactivity with GABA(A) Receptor beta 3 from other species has not been determined.
- Aufreinigung
- Anti-GABA(A) Receptor beta 3 Antibody is directed against rat GABA(A) Receptor beta 3. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected from the following species based on 100% sequence homology: mouse.
- Immunogen
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Immunogen: Anti-GABA(A) Receptor beta 3 Antibody was produced by repeated immunizations with recombinant fusion protein from the cytoplasmic loop of the beta 3 subunit.
Immunogen Type: Recombinant Protein
- Isotyp
- IgG
- Top Product
- Discover our top product GABRB3 Primärantikörper
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- Applikationshinweise
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Immunohistochemistry Dilution: User Optimized
Application Note: Anti-GABA(A) Receptor beta 3 (Rabbit) antibody suitable for use in Western Blotting and Immunohistochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 53 kDa in size corresponding to the beta 3 subunit of GABA A receptor in the appropriate cell lysate or extract.
Western Blot Dilution: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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- Target
- GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))
- Andere Bezeichnung
- GABA(A) Receptor beta 3 (GABRB3 Produkte)
- Synonyme
- GABRB3 antikoerper, eca5 antikoerper, LOC100230475 antikoerper, ECA5 antikoerper, A230092K12Rik antikoerper, AW049585 antikoerper, Cp1 antikoerper, Gabrb-3 antikoerper, beta3 antikoerper, gamma-aminobutyric acid type A receptor beta3 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, beta 3 antikoerper, gamma-aminobutyric acid type A receptor beta 3 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 antikoerper, GABRB3 antikoerper, gabrb3 antikoerper, Gabrb3 antikoerper
- Hintergrund
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Synonyms: Gamma-aminobutyric acid receptor subunit beta-3, GABA(A) receptor subunit beta-3, Gabrb3
Background: Anti-GABA(A) Receptor beta 3 Antibody detects GABA(A) Receptor beta 3. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. GABA(A) receptor beta 3 antibody is ideal for investigators involved in Neuroscience.
Gene Name: GABRB3
- Gen-ID
- 24922
- NCBI Accession
- NP_058761
- UniProt
- P63079
- Pathways
- Sensory Perception of Sound
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