GABRB3 Antikörper (pSer408, pSer409)

Produktnummer ABIN6658226

Hersteller Produkt- Nr.: 612-401-d51

Produktdetails anti-GABRB3 Antikörper

Target: GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))

Bindungsspezifität: pSer408, pSer409

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Hersteller Produkt- Nr.: 612-401-d51

Hersteller: Rockland

Verwendungszweck: GABA(A) Receptor beta 3 phospho S408/phospho S409 Antibody

Kreuzreaktivität (Details): Anti-GABA(A) Receptor beta 3 pS408/pS409 Antibody is directed against rat GABA(A) Receptor beta 3.

Aufreinigung: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GABA(A) Receptor beta 3 pS408/pS409 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser408/Ser409 of rat GABAA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 1:1000

Kommentare:

Anti-GABA(A) Receptor beta 3 pS408/pS409 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 53 kDa in size corresponding to GABA(A) receptor beta 3 subunit phosphorylated at Ser408/Ser409 in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. For extended storage, aliquot contents and freeze at -80° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Referenzen für anti-GABRB3 Antikörper (ABIN6658226)

Garcia, Wolfe, Stewart, Tiemeier, Gookin, Guerrero, Quillinan, Smith: "Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury." in: iScience, Vol. 26, Issue 10, pp. 108061, (2023) (PubMed).

Pribiag, Stellwagen: "TNF-? downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 40, pp. 15879-93, (2013) (PubMed).

Details zu GABRB3

Target: GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))

Andere Bezeichnung: GABA(A) Receptor beta 3 (GABRB3 Produkte)

Hintergrund:

Synonyms: Gamma-aminobutyric acid receptor subunit beta-3, GABA(A) receptor subunit beta-3, Gabrb3, GABA(A) receptor subunit ß-3

Background: Anti-GABA(A) Receptor beta 3 pS408/pS409 Antibody detects GABA(A) Receptor beta 3. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. Phosphorylation of serine 408 and serine 409 within the beta3 subunit have been shown to be critical for the functional modulation of beta3 containing recombinant receptors. GABA(A) Receptor beta 3 pS408/pS409 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRB3

Gen-ID: 24922

NCBI Accession: NP_058761

Pathways: Sensory Perception of Sound