WNK4 Antikörper (Cy3)
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- Target Alle WNK4 Antikörper anzeigen
- WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser WNK4 Antikörper ist konjugiert mit Cy3
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Applikation
- Western Blotting (WB)
- Kreuzreaktivität
- Maus
- Homologie
- Human,Rat
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human WNK4
- Isotyp
- IgG
- Top Product
- Discover our top product WNK4 Primärantikörper
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- Applikationshinweise
- IF(IHC-P) 1:50-200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
- Andere Bezeichnung
- WNK4 (WNK4 Produkte)
- Synonyme
- WNK4 antikoerper, PHA2B antikoerper, PRKWNK4 antikoerper, 2010002J11Rik antikoerper, Pha2b antikoerper, Prkwnk4 antikoerper, Ac2-059 antikoerper, WNK lysine deficient protein kinase 4 antikoerper, WNK4 antikoerper, Wnk4 antikoerper
- Hintergrund
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Synonyms: PHA 2B, PHA2B, PRKWNK 4, PRKWNK4, Protein kinase lysine deficient 4, Protein kinase with no lysine 4, Serine/threonine protein kinase WNK4, WNK lysine deficient protein kinase 4, WNK4_HUMAN.
Background: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.
- Gen-ID
- 65266
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