MMP1 Antikörper (AA 401-464)

Produktnummer ABIN668931

Produktdetails anti-MMP1 Antikörper

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Bindungsspezifität: AA 401-464

Reaktivität: Human, Maus, Ratte, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Schwein, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat MMP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-MMP1 Antikörper (ABIN668931)

Song, Luo, Wang, Li, Yang, Dai, Shen, Zhang, Zhang: "Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats." in: The spine journal : official journal of the North American Spine Society, (2017) (PubMed).

Ding, Wang, Zhu, Zhao, Wu, Chen: "Osteopontin stimulates matrix metalloproteinase expression through the nuclear factor-κB signaling pathway in rat temporomandibular joint and condylar chondrocytes." in: American journal of translational research, Vol. 9, Issue 2, pp. 316-329, (2017) (PubMed).

Elkabir, El-Zehery, Mourad, Soliman, Helal, Refai, Grawish: "Efficacy of azithromycin and metronidazole combined therapy on rats' gingival overgrowth induced by cyclosporine-A: An experimental animal study." in: Journal of oral biology and craniofacial research, Vol. 6, Issue 3, pp. 219-226, (2016) (PubMed).

Mohamed, El-Zehery, Mourad, Grawish: "Impact of three different mouthwashes on the incidence of gingival overgrowth induced by cyclosporine-A: a randomized controlled experimental animal study." in: Oral surgery, oral medicine, oral pathology and oral radiology, Vol. 120, Issue 3, pp. 346-56, (2015) (PubMed).

Jiang, Tian, Wang, Yan, Liu, Liu, Song, Zhang, Shen, Zhang: "Effect of calcitonin pretreatment on naturally occurring intervertebral disc degeneration in guinea pig." in: International journal of clinical and experimental medicine, Vol. 8, Issue 7, pp. 10367-79, (2015) (PubMed).

Luo, Zhang, Wang, Hu, Song, Zhang: "The inhibitory effect of salmon calcitonin on intervertebral disc degeneration in an ovariectomized rat model." in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, (2014) (PubMed).

Details zu MMP1

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Andere Bezeichnung: MMP-1 (MMP1 Produkte)

Synonyme: CLG antikoerper, CLGN antikoerper, Mmp1a antikoerper, CG4859 antikoerper, Dm1-MMP antikoerper, Dmel\\CG4859 antikoerper, MMP-1 antikoerper, MMP1 antikoerper, Mmp 1 antikoerper, dMMP1 antikoerper, dm1-MMP antikoerper, dmmp1 antikoerper, l(2)k04809 antikoerper, mmp1 antikoerper, Mmp1 antikoerper, Mcol-A antikoerper, Mcola antikoerper, col4 antikoerper, mmp18 antikoerper, Clgn antikoerper, matrix metallopeptidase 1 antikoerper, Matrix metalloproteinase 1 antikoerper, matrix metalloproteinase 1 antikoerper, matrix metallopeptidase 1 (interstitial collagenase) antikoerper, matrix metallopeptidase 1a (interstitial collagenase) antikoerper, matrix metallopeptidase 1 S homeolog antikoerper, interstitial collagenase antikoerper, matrix metallopeptidase 8 L homeolog antikoerper, MMP1 antikoerper, Mmp1 antikoerper, RB11133 antikoerper, Mmp1a antikoerper, mmp1.S antikoerper, LOC100727966 antikoerper, mmp8.L antikoerper

Hintergrund:

Synonyms: CLGN, CLG, 27 kDa interstitial collagenase, collagenase, fibroblast, Fibroblast collagenase, Interstitial collagenase, Matrix metallopeptidase 1 interstitial collagenase, Matrix metalloproteinase-1, Matrix metalloprotease 1, Matrix Metalloproteinase 1, MMP-1, MMP1, MMP1_HUMAN, OTTHUMP00000045866, MMP 1.

Background: The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.

Gen-ID: 300339

UniProt: B5DFD5