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PPP4C Antikörper (AA 265-307)

PPP4C Reaktivität: Human, Maus WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN669261
  • Target Alle PPP4C Antikörper anzeigen
    PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))
    Bindungsspezifität
    • 15
    • 14
    • 10
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 265-307
    Reaktivität
    • 71
    • 51
    • 21
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 72
    • 10
    • 3
    • 1
    Kaninchen
    Klonalität
    • 78
    • 8
    Polyklonal
    Konjugat
    • 36
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PPP4C Antikörper ist unkonjugiert
    Applikation
    • 70
    • 29
    • 28
    • 25
    • 25
    • 10
    • 9
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus
    Homologie
    Rat,Dog,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PP4C
    Isotyp
    IgG
    Top Product
    Discover our top product PPP4C Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))
    Andere Bezeichnung
    PPP4C (PPP4C Produkte)
    Synonyme
    pp4 antikoerper, ppx antikoerper, pp4c antikoerper, pph3 antikoerper, MGC75928 antikoerper, PP4C-A antikoerper, gc:56413 antikoerper, ppp4c antikoerper, wu:fd05e08 antikoerper, zgc:56413 antikoerper, PP4 antikoerper, PP4C antikoerper, PPH3 antikoerper, PPP4 antikoerper, PPX antikoerper, 1110002D08Rik antikoerper, AU016079 antikoerper, Ppx antikoerper, protein phosphatase 4 catalytic subunit antikoerper, protein phosphatase 4, catalytic subunit a antikoerper, protein phosphatase 4, catalytic subunit antikoerper, protein phosphatase 4 catalytic subunit S homeolog antikoerper, ppp4c antikoerper, ppp4ca antikoerper, PPP4C antikoerper, Ppp4c antikoerper, ppp4c.S antikoerper
    Hintergrund

    Synonyms: PP4, PPX, PP4C, PPH3, PPP4, Serine/threonine-protein phosphatase 4 catalytic subunit, Protein phosphatase X, PP-X, PPP4C

    Background: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-14 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

    Gen-ID
    5531
    UniProt
    P60510
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