tau Antikörper (Atto 488)
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- Target Alle tau Antikörper anzeigen
- tau (tau Protein)
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser tau Antikörper ist konjugiert mit Atto 488
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- Detects ~45.8kda.
- Aufreinigung
- Protein A Purified
- Immunogen
- Synthetic peptide from the full length of Human Tau
- Top Product
- Discover our top product tau Primärantikörper
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- Applikationshinweise
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- WB (1:1000)
- optimal dilutions for assays should be determined by the user.
- optimal dilutions for assays should be determined by the user.
- Kommentare
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A 1:1000 dilution of ABIN6698757 was sufficient for detection of Tau in 10 μg of human SH-SY5Y cell lysate cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
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- Target
- tau (tau Protein)
- Andere Bezeichnung
- Tau (tau Produkte)
- Synonyme
- DDPAC antikoerper, FTDP-17 antikoerper, MAPTL antikoerper, MSTD antikoerper, MTBT1 antikoerper, MTBT2 antikoerper, PPND antikoerper, TAU antikoerper, tau antikoerper, PHF-tau antikoerper, microtubule associated protein tau antikoerper, MAPT antikoerper
- Hintergrund
- Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
- Gen-ID
- 4137
- UniProt
- P10636
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