SMAD7 Antikörper (AA 1-100)

Produktnummer ABIN670206

Produktdetails anti-SMAD7 Antikörper

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Bindungsspezifität: AA 1-100

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Cow,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Smad7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SMAD7 Antikörper (ABIN670206)

Yang, Ding, Xu, Chen, Ding: "MicroRNA-15a inhibition protects against hypoxia/reoxygenation-induced apoptosis of cardiomyocytes by targeting mothers against decapentaplegic homolog 7." in: Molecular medicine reports, Vol. 15, Issue 6, pp. 3699-3705, (2017) (PubMed).

Liu, Shi, Yang, Zhao, Du, Zou, Yu: "Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy." in: Synapse (New York, N.Y.), Vol. 68, Issue 6, pp. 275-82, (2014) (PubMed).

Kou, Hu, Yao, Wang, Shen, Kang, Hong: "Transforming growth factor-?1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 62, Issue 3, pp. 283-9, (2013) (PubMed).

Details zu SMAD7

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Andere Bezeichnung: Smad7 (SMAD7 Produkte)

Synonyme: CRCS3 antikoerper, MADH7 antikoerper, MADH8 antikoerper, Smad7a antikoerper, Madh7 antikoerper, Smad10 antikoerper, madh7 antikoerper, xsmad7 antikoerper, wu:fj60c10 antikoerper, SMAD family member 7 antikoerper, SMAD family member 7 L homeolog antikoerper, SMAD7 antikoerper, Smad7 antikoerper, smad7.L antikoerper, smad7 antikoerper

Hintergrund:

Synonyms: CRCS3, MADH7, MADH8, Mothers against decapentaplegic homolog 7, MAD homolog 7, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 8, MAD homolog 8, Mothers against DPP homolog 8, SMAD family member 7, SMAD 7, Smad7, hSMAD7

Background: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).

Molekulargewicht: 46kDa

Gen-ID: 4092

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization