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DNMT1 Antikörper (AA 21-120)

Name: DNMT1 Antikörper (AA 21-120)
SKU: ABIN671796
Price: 384.62 EUR
Availability: InStock

DNMT1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

Formalin-fixed and paraffin embedded mouse lymphoma tissue labeled with Anti-Dnmt1 Polyclonal Antibody, Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining (DNMT1 Antikörper (AA 21-120))

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-Dnmt1 Polyclonal Antibody, Unconjugated (ABIN671796) at 1:200, followed by conjugation to the secondary antibody and DAB staining (DNMT1 Antikörper (AA 21-120))

IHC

Formalin-fixed and paraffin embedded mouse lymphoma tissue labeled with Anti-Dnmt1 Polyclonal Antibody, Unconjugated (ABIN671796) at 1:200, followed by conjugation to the secondary antibody and DAB staining (DNMT1 Antikörper (AA 21-120))

IHC

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-Dnmt1 Polyclonal Antibody, Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining (DNMT1 Antikörper (AA 21-120))

IHC (p)

4 Abbildungen

(1 reference)

Produktnummer ABIN671796

Datenblatt (PDF)

Target Alle DNMT1 Antikörper anzeigen

DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
Bindungsspezifität
22

21

16

12

12

10

9

8

7

5

4

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 21-120
Reaktivität
177

39

30

3

1

1

1

1

1

1

1
Human, Maus, Ratte
Wirt
138

39

1

1
Kaninchen
Passende Sekundärantikörper
Klonalität
127

52
Polyklonal
Konjugat
77

13

13

11

8

8

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1
Dieser DNMT1 Antikörper ist unkonjugiert
Applikation
115

64

45

40

31

28

21

15

14

13

11

5

4

3

3

2

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität

This antibody will not recongize isoform 3.

Kreuzreaktivität

Human, Maus, Ratte

Homologie

Dog,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung

Purified by Protein A.

Immunogen

KLH conjugated synthetic peptide derived from human Dnmt1

Isotyp

IgG

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anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 22-126) antibody
DNMT1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel

ProClin

Vorsichtsmaßnahmen

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit

12 months
Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: "Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition." in: Oncotarget, (2015) (PubMed).
Target

DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Andere Bezeichnung

Dnmt1 (DNMT1 Produkte)

Hintergrund

Synonyms: AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN, DNA (cytosine-5)-methyltransferase 1, Dnmt1, CXXC-type zinc finger protein 9, DNA methyltransferase HsaI, DNA MTase HsaI, M.HsaI
Background: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

Gen-ID

1786

UniProt

P26358

Pathways

SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion