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RMI2 Antikörper

RMI2 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6719656
  • Target Alle RMI2 Antikörper anzeigen
    RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 1
    Kaninchen
    Klonalität
    • 1
    Polyklonal
    Konjugat
    • 1
    Dieser RMI2 Antikörper ist unkonjugiert
    Applikation
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for RMI2 detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Sequenz
    KMTDLSDNPI HESMWELEVE DLHRNIP
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for RMI2 detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence of human RMI2(KMTDLSDNPIHESMWELEVEDLHRNIP).
    Isotyp
    IgG
    Top Product
    Discover our top product RMI2 Primärantikörper
  • Applikationshinweise

    Application details: Western blot|0.1-0.5 μg/mL Immunohistochemistry(Paraffin-embedded Section)|0.5-1 μg/mL

    Kommentare

    Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))
    Andere Bezeichnung
    RMI2 (RMI2 Produkte)
    Synonyme
    BLAP18 antikoerper, C16orf75 antikoerper, C25H16orf75 antikoerper, C14H16orf75 antikoerper, A630055G03Rik antikoerper, Gm537 antikoerper, Gm929 antikoerper, RecQ mediated genome instability 2 antikoerper, RMI2 antikoerper, Rmi2 antikoerper
    Hintergrund

    Synonyms: RecQ-mediated genome instability protein 2, hRMI2, BLM-associated protein of 18 kDa, BLAP18, RMI2, C16orf75

    Background: RMI2 is a component of the BLM (RECQL3) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability. This gene is mapped to 16p13.13. RMI1 and RMI2 were present in approximately stoichiometric amounts with other BLM complex components, including topoisomerase-3-alpha (TOP3A), RPA (see RPA1), and BLAP250. RMI2 also associated with RMI1 and TOP3A in a second complex. RMI1 and RMI2 interacted directly, and both were essential for stability of the BLM complex. Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90 % . Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange, but other functions of the BLM complex appeared intact. Mutation analysis revealed that interaction between human RMI2 and BLM was essential for suppression of sister chromatid exchange.

    Gen-ID
    116028
    UniProt
    Q96E14
    Pathways
    DNA Reparatur
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