TRAF2 Antikörper (AA 401-501)

Produktnummer ABIN673479

Produktdetails anti-TRAF2 Antikörper

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Bindungsspezifität: AA 401-501

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human

Homologie: Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TRAF2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TRAF2 Antikörper (ABIN673479)

Lei, Bai, Yang, Lai, Qiu, Yang, Lian: "Gsdma3 is a new factor needed for TNF-?-mediated apoptosis signal pathway in mouse skin keratinocytes." in: Histochemistry and cell biology, Vol. 138, Issue 3, pp. 385-96, (2012) (PubMed).

Details zu TRAF2

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Andere Bezeichnung: TRAF2 (TRAF2 Produkte)

Synonyme: MGC:45012 antikoerper, TRAP antikoerper, TRAP3 antikoerper, TANK antikoerper, AI325259 antikoerper, TNF-receptor-associated factor 2 antikoerper, conjugal transfer protein TraF antikoerper, TNF receptor associated factor 2 antikoerper, TNF receptor-associated factor 2 antikoerper, Tnf receptor-associated factor 2 antikoerper, LOC661716 antikoerper, traF2 antikoerper, TRAF2 antikoerper, Traf2 antikoerper

Hintergrund:

Synonyms: TRAP, TRAP3, MGC:4512, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2, Tumor necrosis factor type 2 receptor-associated protein 3, TRAF2

Background: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Gen-ID: 7186

UniProt: Q12933

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteine