RASSF1 Antikörper (AA 145-260)

Produktnummer ABIN673764

Produktdetails anti-RASSF1 Antikörper

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Bindungsspezifität: AA 145-260

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASSF1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Cow,Sheep,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RASSF1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-RASSF1 Antikörper (ABIN673764)

Klacz, Wierzbicki, Wronska, Rybarczyk, Stanislawowski, Slebioda, Olejniczak, Matuszewski, Kmiec: "Decreased expression of RASSF1A tumor suppressor gene is associated with worse prognosis in clear cell renal cell carcinoma." in: International journal of oncology, Vol. 48, Issue 1, pp. 55-66, (2015) (PubMed).

Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: "CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine." in: Biochemical and biophysical research communications, Vol. 402, Issue 3, pp. 507-14, (2010) (PubMed).

Details zu RASSF1

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Andere Bezeichnung: RASSF1 (RASSF1 Produkte)

Synonyme: RASSF1 antikoerper, zgc:92505 antikoerper, wu:fc17f02 antikoerper, zgc:112224 antikoerper, 123F2 antikoerper, NORE2A antikoerper, RASSF1A antikoerper, RDA32 antikoerper, REH3P21 antikoerper, AA536941 antikoerper, AU044980 antikoerper, Rassf1A antikoerper, Rassf1B antikoerper, Rassf1C antikoerper, NPR2-like, GATOR1 complex subunit antikoerper, Ras association (RalGDS/AF-6) domain family 1 antikoerper, Ras association domain family member 1 antikoerper, putative rassf1 antikoerper, Ras association domain family member 1 L homeolog antikoerper, Ras association (RalGDS/AF-6) domain family member 1 antikoerper, NPRL2 antikoerper, rassf1 antikoerper, RASSF1 antikoerper, Smp_157340 antikoerper, rassf1.L antikoerper, Rassf1 antikoerper

Hintergrund:

Synonyms: 123F2, RDA32, NORE2A, RASSF1A, REH3P21, Ras association domain-containing protein 1, RASSF1

Background: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF1 stimulation. Isoform A interacts with CDC2, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Gen-ID: 11186

UniProt: Q9NS23