WNK3 Antikörper (AA 451-550) (FITC)
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- Target Alle WNK3 Antikörper anzeigen
- WNK3 (WNK Lysine Deficient Protein Kinase 3 (WNK3))
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Bindungsspezifität
- AA 451-550
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser WNK3 Antikörper ist konjugiert mit FITC
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Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Kreuzreaktivität
- Human, Ratte
- Homologie
- Mouse,Cow,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human WNK3 protein
- Isotyp
- IgG
- Top Product
- Discover our top product WNK3 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- WNK3 (WNK Lysine Deficient Protein Kinase 3 (WNK3))
- Andere Bezeichnung
- Wnk3 Protein (WNK3 Produkte)
- Synonyme
- fc63h12 antikoerper, PRKWNK3 antikoerper, Prkwnk3 antikoerper, Wnk3-ps antikoerper, RGD1563131 antikoerper, wu:fc63h12 antikoerper, WNK lysine deficient protein kinase 3 antikoerper, wu:fc63h12 antikoerper, LOC100363278 antikoerper, WNK3 antikoerper, Wnk3 antikoerper
- Hintergrund
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Synonyms: PRKWNK3, Serine/threonine-protein kinase WNK3, Protein kinase lysine-deficient 3, Protein kinase with no lysine 3, WNK3, KIAA1566
Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.
- Gen-ID
- 65267
- UniProt
- Q9BYP7
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