MITF Antikörper (AA 351-450)
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- Target Alle MITF Antikörper anzeigen
- MITF (Microphthalmia-Associated Transcription Factor (MITF))
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Bindungsspezifität
- AA 351-450
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MITF Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Maus
- Homologie
- Human,Rat,Dog,Cow,Horse,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human MITF
- Isotyp
- IgG
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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Melanoblast development coincides with the late emerging cells from the dorsal neural tube in turtle Trachemys scripta." in: Scientific reports, Vol. 7, Issue 1, pp. 12063, (2019) (PubMed).
: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." in: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).
: "Antimelanogenesis Activity of Hydrolyzed Ginseng Extract (GINST) via Inhibition of JNK Mitogen-activated Protein Kinase in B16F10 Cells." in: Journal of food science, Vol. 81, Issue 8, pp. H2085-92, (2016) (PubMed).
: "
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Melanoblast development coincides with the late emerging cells from the dorsal neural tube in turtle Trachemys scripta." in: Scientific reports, Vol. 7, Issue 1, pp. 12063, (2019) (PubMed).
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- Target
- MITF (Microphthalmia-Associated Transcription Factor (MITF))
- Andere Bezeichnung
- Mitf (MITF Produkte)
- Hintergrund
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Synonyms: MI, WS2, CMM8, WS2A, bHLHe32, Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, MITF
Background: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
- Gen-ID
- 4286
- UniProt
- O75030
- Pathways
- Chromatin Binding
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