MITF Antikörper (AA 351-450)

Produktnummer ABIN676373

Produktdetails anti-MITF Antikörper

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Bindungsspezifität: AA 351-450

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MITF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MITF

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-MITF Antikörper (ABIN676373)

Rice, Cebra-Thomas, Haugas, Partanen, Rice, Gilbert: "Melanoblast development coincides with the late emerging cells from the dorsal neural tube in turtle Trachemys scripta." in: Scientific reports, Vol. 7, Issue 1, pp. 12063, (2019) (PubMed).

Kito, Saigo, Takeuchi: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." in: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).

Han, Sung, Lee: "Antimelanogenesis Activity of Hydrolyzed Ginseng Extract (GINST) via Inhibition of JNK Mitogen-activated Protein Kinase in B16F10 Cells." in: Journal of food science, Vol. 81, Issue 8, pp. H2085-92, (2016) (PubMed).

Details zu MITF

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Andere Bezeichnung: Mitf (MITF Produkte)

Synonyme: MITF antikoerper, ws2a antikoerper, mitfa antikoerper, MITF-A antikoerper, LOC100313655 antikoerper, mitfb antikoerper, CMM8 antikoerper, MI antikoerper, WS2 antikoerper, WS2A antikoerper, bHLHe32 antikoerper, BCC2 antikoerper, Bhlhe32 antikoerper, Gsfbcc2 antikoerper, Vitiligo antikoerper, Wh antikoerper, bw antikoerper, mi antikoerper, vit antikoerper, MITF-H antikoerper, MITF-M antikoerper, CMI9 antikoerper, melanogenesis associated transcription factor antikoerper, microphthalmia-associated transcription factor antikoerper, microphthalmia-associated transcription factor S homeolog antikoerper, Microphthalmia antikoerper, MITF antikoerper, mitf antikoerper, LOC100313655 antikoerper, mitf.S antikoerper, LOC100534525 antikoerper, MICROP antikoerper, Mitf antikoerper

Hintergrund:

Synonyms: MI, WS2, CMM8, WS2A, bHLHe32, Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, MITF

Background: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Gen-ID: 4286

UniProt: O75030

Pathways: Chromatin Binding