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AU5 Epitope Tag Antikörper

TDFYLK Reaktivität: Tag ELISA, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN677708
  • Target Alle AU5 Epitope Tag (TDFYLK) Produkte
    AU5 Epitope Tag (TDFYLK)
    Reaktivität
    Tag
    Wirt
    • 4
    • 3
    Kaninchen
    Klonalität
    • 7
    Polyklonal
    Konjugat
    • 5
    • 1
    • 1
    Dieser AU5 Epitope Tag Antikörper ist unkonjugiert
    Applikation
    • 7
    • 5
    • 5
    • 3
    • 2
    ELISA, Immunocytochemistry (ICC)
    Sequenz
    TDFYLK
    Kreuzreaktivität
    Tag
    Kreuzreaktivität (Details)
    fusion protein,tagged T7 tag
    Produktmerkmale
    Antibody is specific for: fusion protein,tagged T7 tag
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated to AU5 tag
    Isotyp
    IgG
  • Applikationshinweise
    ELISA 1:500-1000
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    AU5 Epitope Tag (TDFYLK)
    Andere Bezeichnung
    AU5 tag (TDFYLK Produkte)
    Substanzklasse
    Tag
    Hintergrund

    Synonyms: AU5 epitope tag, TDFYLK epitope tag, TDFYLK tag.

    Background: Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptors-induced apoptosis remains controvertial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Secreted core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage.

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