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MTDH Antikörper (AA 131-230)

MTDH Reaktivität: Human WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN678863
  • Target Alle MTDH Antikörper anzeigen
    MTDH (Metadherin (MTDH))
    Bindungsspezifität
    • 15
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 131-230
    Reaktivität
    • 49
    • 18
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 40
    • 7
    • 3
    Kaninchen
    Klonalität
    • 45
    • 5
    Polyklonal
    Konjugat
    • 28
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTDH Antikörper ist unkonjugiert
    Applikation
    • 40
    • 14
    • 12
    • 12
    • 11
    • 9
    • 8
    • 8
    • 7
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Dog,Cow,Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human AEG-1
    Isotyp
    IgG
    Top Product
    Discover our top product MTDH Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Zhang, Li, Qian, Liu, Guo, Lin: "MTDH/AEG-1-based DNA vaccine suppresses metastasis and enhances chemosensitivity to paclitaxel in pelvic lymph node metastasis." in: Biomedicine & pharmacotherapy, Vol. 70, pp. 217-26, (2015) (PubMed).

    Guo, Zhang, Liu, Wang, Liu, Wang, Ma, Wu: "Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis." in: Journal of pediatric urology, Vol. 10, Issue 2, pp. 317-23, (2014) (PubMed).

    Zheng, Li, Wu, Liu, Sun, Yang, Hao, Sheng, Sun, Zhang, Long, Liang, Hu et al.: "Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune ..." in: Tumour biology, Vol. 35, Issue 5, pp. 4219-24, (2014) (PubMed).

    Guo, Chen, Xi, Chang, Zhang, Zhang: "AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues." in: Journal of biomedical research, Vol. 28, Issue 5, pp. 388-95, (2014) (PubMed).

  • Target
    MTDH (Metadherin (MTDH))
    Andere Bezeichnung
    LYRIC (MTDH Produkte)
    Synonyme
    MGC75963 antikoerper, 2610103J23Rik antikoerper, 3D3 antikoerper, 3D3/Lyric antikoerper, AEG-1 antikoerper, AV353288 antikoerper, D8Bwg1112e antikoerper, Lyric antikoerper, AEG1 antikoerper, LYRIC antikoerper, LYRIC/3D3 antikoerper, metadherin antikoerper, mtdh antikoerper, MTDH antikoerper, Mtdh antikoerper
    Hintergrund

    Synonyms: 3D3, AEG1, AEG-1, LYRIC, LYRIC/3D3, Protein LYRIC, 3D3/LYRIC, Astrocyte elevated gene-1 protein, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein, MTDH

    Background: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

    Gen-ID
    92140
    UniProt
    Q86UE4
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
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