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Klotho Antikörper (AA 401-500)

KL Reaktivität: Human, Maus, Ratte IHC (p), IHC (fro), IF (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN681778
  • Target Alle Klotho (KL) Antikörper anzeigen
    Klotho (KL)
    Bindungsspezifität
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reaktivität
    • 31
    • 28
    • 12
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 41
    • 4
    • 2
    • 1
    Kaninchen
    Klonalität
    • 35
    • 13
    Polyklonal
    Konjugat
    • 29
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Klotho Antikörper ist unkonjugiert
    Applikation
    • 35
    • 22
    • 12
    • 9
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Klotho
    Isotyp
    IgG
    Top Product
    Discover our top product KL Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Prudhomme, Glinka, Kurt, Liu, Wang: "The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells." in: Biochemical and biophysical research communications, Vol. 493, Issue 4, pp. 1542-1547, (2017) (PubMed).

  • Target
    Klotho (KL)
    Andere Bezeichnung
    Klotho (KL Produkte)
    Synonyme
    alpha-kl antikoerper, KL antikoerper, LOC100223456 antikoerper, klotho antikoerper, Klotho antikoerper, KL antikoerper, Kl antikoerper, kl antikoerper, LOC100533542 antikoerper
    Hintergrund

    Synonyms: Klotho, KL

    Background: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

    Gen-ID
    9365
    UniProt
    Q9UEF7
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hormone Activity, Growth Factor Binding
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