MFN2 Antikörper (AA 1-120)

Produktnummer ABIN682528

Produktdetails anti-MFN2 Antikörper

Target: MFN2 (Mitofusin 2 (MFN2))

Bindungsspezifität: AA 1-120

Reaktivität: Human, Maus, Ratte, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MFN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Mitofusin 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-MFN2 Antikörper (ABIN682528)

Hui, Lu, Han, Zhou, Liu, Li, Jin: "Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats." in: Acta histochemica, Vol. 119, Issue 4, pp. 392-399, (2017) (PubMed).

Ku, Ji, Zhang, Li, Sang: "PM2.5, SO2 and NO2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain." in: Chemosphere, Vol. 163, pp. 27-34, (2016) (PubMed).

Details zu MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Andere Bezeichnung: Mitofusin 2 (MFN2 Produkte)

Synonyme: CG3869 antikoerper, Dmel\\CG3869 antikoerper, MARF antikoerper, Marf-1 antikoerper, Mfn antikoerper, anon-WO0125274.3 antikoerper, dMFN antikoerper, dMfn antikoerper, dmfn antikoerper, marf antikoerper, mfn antikoerper, mfn2 antikoerper, MFN2 antikoerper, hsg antikoerper, cmt2a antikoerper, cprp1 antikoerper, cmt2a2 antikoerper, CMT2A antikoerper, CMT2A2 antikoerper, CPRP1 antikoerper, HSG antikoerper, D630023P19Rik antikoerper, Fzo antikoerper, mg:cb01g09 antikoerper, si:dkeyp-104h9.2 antikoerper, wu:fb79a11 antikoerper, mitofusin 2 antikoerper, Mitochondrial assembly regulatory factor antikoerper, mitofusin-2 antikoerper, mitofusin 2 L homeolog antikoerper, MFN2 antikoerper, Marf antikoerper, mfn2 antikoerper, LOC100186475 antikoerper, Mfn2 antikoerper, mfn2.L antikoerper

Hintergrund:

Synonyms: HSG, MARF, CMT2A, CPRP1, CMT2A2, Mitofusin-2, Transmembrane GTPase MFN2, MFN2, KIAA0214

Background: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.

Gen-ID: 9927

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development