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beta Catenin Antikörper (pSer33, pSer37)

Name: beta Catenin Antikörper (pSer33, pSer37)
SKU: ABIN683893
Price: 384.62 EUR
Availability: InStock

CATNB Reaktivität: Human, Maus, Ratte WB, FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

Formalin-fixed and paraffin embedded human breast carcinoma labeled with Anti-Phospho-Beta-Catenin(Ser33/37) Polyclonal Antibody, Unconjugated (ABIN683893) at 1:200 followed by conjugation to the secondary antibody and DAB staining (beta Catenin Antikörper (pSer33, pSer37))

IHC

Formalin-fixed and paraffin embedded human cervical carcinoma labeled with Anti-Phospho-Beta-Catenin(Ser33/37) Polyclonal Antibody, Unconjugated (ABIN683893) at 1:200 followed by conjugation to the secondary antibody and DAB staining (beta Catenin Antikörper (pSer33, pSer37))

IHC

Formalin-fixed and paraffin embedded human colon cancer tissue labeled with Anti-Beta-Catenin (Ser33 + 37) Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining. (beta Catenin Antikörper (pSer33, pSer37))

IHC (p)

Formalin-fixed and paraffin embedded human laryngeal carcinoma labeled with Rabbit Anti-Beta-Catenin (Ser33 + 37) Polyclonal Antibody at 1:200 followed by conjugation to the secondary antibody and DAB staining (beta Catenin Antikörper (pSer33, pSer37))

IF (p)

Formalin-fixed and paraffin embedded rat brain labeled with Anti-Beta-Catenin (Ser33 + 37) Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining. (beta Catenin Antikörper (pSer33, pSer37))

IHC (p)

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-Beta-Catenin (Ser33 + 37) Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining. (beta Catenin Antikörper (pSer33, pSer37))

IHC (p)

7 Abbildungen

(1 reference)

Produktnummer ABIN683893

Datenblatt (PDF)

Target Alle beta Catenin (CATNB) Antikörper anzeigen

beta Catenin (CATNB) (Catenin, beta (CATNB))
Bindungsspezifität
49

27

25

25

23

19

17

17

16

16

16

15

10

8

7

7

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer33, pSer37
Reaktivität
345

255

233

28

23

22

18

17

7

5

5

5

1

1

1

1

1

1

1

1
Human, Maus, Ratte
Wirt
286

59

4

1

1
Kaninchen
Passende Sekundärantikörper
Klonalität
279

72
Polyklonal
Konjugat
131

22

11

10

9

9

9

9

9

9

9

9

9

9

9

8

8

7

7

7

7

7

4

4

4

4

4

4

1

1

1
Dieser beta Catenin Antikörper ist unkonjugiert
Applikation
215

158

119

117

79

65

64

51

35

31

23

9

7

4

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität

These phosphorylation sites are homologous to Ser33 + Ser37 in Mouse and Rat.

Kreuzreaktivität

Human, Maus, Ratte

Homologie

Pig,Chicken,Rabbit

Aufreinigung

Purified by Protein A.

Immunogen

KLH conjugatedsynthetic phosphopeptide derived from human Beta-Catenin around the phosphorylation site of Ser33/37

Isotyp

IgG

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Applikationshinweise

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel

ProClin

Vorsichtsmaßnahmen

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit

12 months
Wang, Tang, He, Shi, Kang, Lyu, Zhou, Zhu, Zhang, Tang: "High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/β-Catenin Pathway." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 50, Issue 6, pp. 2046-2059, (2018) (PubMed).
Target

beta Catenin (CATNB) (Catenin, beta (CATNB))

Andere Bezeichnung

beta Catenin (CATNB Produkte)

Synonyme

Bfc antikoerper, Catnb antikoerper, Mesc antikoerper, CTNNB antikoerper, MRD19 antikoerper, armadillo antikoerper, ctnnb antikoerper, id:ibd2058 antikoerper, wu:fb73e10 antikoerper, wu:fi81c06 antikoerper, wu:fk25h01 antikoerper, beta-catenin antikoerper, ctnnb1 antikoerper, CHBCAT antikoerper, catenin (cadherin associated protein), beta 1 antikoerper, catenin beta 1 antikoerper, catenin (cadherin-associated protein), beta 1 antikoerper, catenin beta 1 L homeolog antikoerper, Ctnnb1 antikoerper, CTNNB1 antikoerper, ctnnb1 antikoerper, ctnnb1.L antikoerper

Hintergrund

Synonyms: CTNNB, MRD19, armadillo, Catenin beta-1, Beta-catenin, CTNNB1, OK/SW-cl.35, PRO2286
Background: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

Gen-ID

1499

UniProt

P35222

Pathways

Peptide Hormone Metabolism