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TLR3 Antikörper (AA 801-905)

Name: TLR3 Antikörper (AA 801-905)
SKU: ABIN686617
Price: 384.62 EUR
Availability: InStock

TLR3 Reaktivität: Human, Maus, Ratte WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

Formalin-fixed and paraffin embedded human placenta labeled with Rabbit Anti TLR3 Polyclonal Antibody, Unconjugated (ABIN686617) at 1:200 followed by conjugation to the secondary antibody and DAB staining (TLR3 Antikörper (AA 801-905))

IHC

Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-TLR3 Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining (TLR3 Antikörper (AA 801-905))

IHC (p)

Paraformaldehyde-fixed, paraffin embedded rat kidney tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-TLR3 Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining (TLR3 Antikörper (AA 801-905))

IHC (p)

Paraformaldehyde-fixed, paraffin embedded rat lung tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-TLR3 Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining (TLR3 Antikörper (AA 801-905))

IHC (p)

4 Abbildungen

(4 Referenzen)

Produktnummer ABIN686617

Datenblatt (PDF)

Target Alle TLR3 Antikörper anzeigen

TLR3 (Toll-Like Receptor 3 (TLR3))
Bindungsspezifität
15

10

8

8

5

4

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 801-905
Reaktivität
95

63

29

6

2

1

1

1
Human, Maus, Ratte
Wirt
80

31

5

2
Kaninchen
Passende Sekundärantikörper
Klonalität
83

35
Polyklonal
Konjugat
48

18

15

9

6

5

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser TLR3 Antikörper ist unkonjugiert
Applikation
78

42

35

33

21

14

14

13

12

12

7

4

4

3

2

1
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität

Human, Maus, Ratte

Homologie

Dog,Pig

Aufreinigung

Purified by Protein A.

Immunogen

KLH conjugated synthetic peptide derived from mouse TLR3

Isotyp

IgG

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Applikationshinweise

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel

ProClin

Vorsichtsmaßnahmen

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit

12 months
Zhao, Zhang, Wang, Jin, Zhou, Chen, Su: "Activation of Toll-like receptor 3 promotes pathological corneal neovascularization by enhancement of SDF-1-mediated endothelial progenitor cell recruitment." in: Experimental eye research, Vol. 178, pp. 177-185, (2019) (PubMed).

Zhu, Xu, Jiang, Wang, Geng, Wu, Hussain, Gao, Han, Li, Lan, Ning, Zhang, Holmdahl, Meng, Lu: "Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis." in: Clinical immunology (Orlando, Fla.), Vol. 175, pp. 56-68, (2016) (PubMed).

Wang, Lei, Zhang, Zhao, Fang, Lai, Han, Xiao, Wang: "Xenobiotic Pregnane X Receptor (PXR) Regulates Innate Immunity via Activation of NLRP3 Inflammasome in Vascular Endothelial Cells." in: The Journal of biological chemistry, Vol. 289, Issue 43, pp. 30075-81, (2014) (PubMed).

Zhu, Meng, Jiang, Xu, Wang, Han, Lu: "Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats." in: Scandinavian journal of immunology, Vol. 76, Issue 3, pp. 263-70, (2012) (PubMed).
Target

TLR3 (Toll-Like Receptor 3 (TLR3))

Andere Bezeichnung

TLR3 (TLR3 Produkte)

Synonyme

CD283 antikoerper, IIAE2 antikoerper, AI957183 antikoerper, zgc:123006 antikoerper, toll like receptor 3 antikoerper, toll-like receptor 3 antikoerper, TLR3 antikoerper, Tlr3 antikoerper, tlr3 antikoerper

Hintergrund

Synonyms: AI957183, Toll-like receptor 3, CD283, Tlr3
Background: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity).

Gen-ID

142980

UniProt

Q99MB1

Pathways

TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades