GREM1 Antikörper (AA 101-184)

Produktnummer ABIN687082

Produktdetails anti-GREM1 Antikörper

Target: GREM1 (Gremlin 1 (GREM1))

Bindungsspezifität: AA 101-184

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GREM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human gremlin 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-GREM1 Antikörper (ABIN687082)

Wellbrock, Sheikhzadeh, Oliveira-Ferrer, Stamm, Hillebrand, Keyser, Klokow, Vohwinkel, Bonk, Otto, Streichert, Balabanov, Hagel, Rybczynski, Bentzien, Bokemeyer, von Kodolitsch, Fiedler: "Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection." in: PLoS ONE, Vol. 9, Issue 8, pp. e104742, (2014) (PubMed).

Details zu GREM1

Target: GREM1 (Gremlin 1 (GREM1))

Andere Bezeichnung: Gremlin 1 (GREM1 Produkte)

Synonyme: grem1 antikoerper, MGC136702 antikoerper, zgc:136702 antikoerper, GREM1 antikoerper, drm antikoerper, pig2 antikoerper, dand2 antikoerper, ihg-2 antikoerper, gremlin antikoerper, Cktsf1b1 antikoerper, Drm antikoerper, Grem antikoerper, ld antikoerper, gremlin-1 antikoerper, CKTSF1B1 antikoerper, DAND2 antikoerper, DRM antikoerper, GREMLIN antikoerper, IHG-2 antikoerper, cktsf1b1 antikoerper, gremlin 1a, DAN family BMP antagonist antikoerper, gremlin 1, DAN family BMP antagonist antikoerper, gremlin 1 antikoerper, gremlin 1, DAN family BMP antagonist L homeolog antikoerper, grem1a antikoerper, GREM1 antikoerper, LOC662541 antikoerper, grem1 antikoerper, Grem1 antikoerper, grem1.L antikoerper

Hintergrund:

Synonyms: DRM, HMPS, PIG2, CRAC1, DAND2, IHG-2, GREMLIN, CKTSF1B1, Gremlin-1, Cell proliferation-inducing gene 2 protein, Cysteine knot superfamily 1, BMP antagonist 1, DAN domain family member 2, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, GREM1

Background: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity).

Gen-ID: 26585

UniProt: O60565

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location