RAS Antikörper
-
- Target Alle RAS Produkte
- RAS
-
Reaktivität
- Human, Ratte
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser RAS Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Human, Ratte
- Homologie
- Mouse,Dog,Cow,Sheep,Pig,Horse
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Pan-ras
- Isotyp
- IgG
-
anti-RAS (AA 31-43) antibody (HRP)
Reaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal HRP
anti-RAS (AA 31-43) antibodyReaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-RAS (AA 31-43) antibody (FITC)Reaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal FITC
anti-RAS (AA 31-43) antibody (Alkaline Phosphatase (AP))Reaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal Alkaline Phosphatase (AP)
anti-RAS (AA 31-43) antibody (APC)Reaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal APC
anti-RAS (AA 31-43) antibody (Atto 488)Reaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal Atto 488
anti-RAS (AA 31-43) antibody (Atto 594)Reaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal Atto 594
anti-RAS (AA 31-43) antibody (Atto 390)Reaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal Atto 390
anti-RAS (AA 1-190) antibodyReaktivität: Human, Ratte, Maus, Huhn, Hund WB, IHC, IF, IP Wirt: Maus Monoclonal 18-Ras unconjugated
anti-RAS antibodyReaktivität: Human, Ratte, Maus, Rind (Kuh) WB Wirt: Kaninchen Polyclonal unconjugated
-
- Applikationshinweise
-
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- RAS
- Abstract
- RAS Produkte
- Synonyme
- asr antikoerper, resistance to audiogenic seizures antikoerper, ras antikoerper
- Hintergrund
-
Synonyms: K-Ras, P21 protein, p21ras, H-Ras-1, c-H-ras, N-Ras.
Background: RAS superfamily comprises around 50 related genes encoding GTP-binding domain (G-proteins) involved in signal transduction. The main genes are HRAS, NRAS and KRAS. Ras proteins are membrane-bound GTPases. The inactive form is GDP-bound. They are activated by ligand-binding receptor tyrosine kinases such as EGFR, PDGFR, colony-stimulating factor and fibroblast growth factor. These kinases transiently convert RAS-GDP to RAS-GTP, the active form of RAS. Single amino acid substitutions can activate RAS making it highly oncogenic. Such mutations generally reduce the GTPase activity of RAS, prolonging it in its active GTP-bound form. The consequence of this is sustained activation of the RAF1-MAPK signalling pathway. RAS mutations are found in 10-15 % of tumours. A high incidence of RAS mutations is found in pancreatic cancers.
-
