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Rekombinanter MHC Class II HLA-DP/DQ/DR Antikörper

HLA-DP/DQ/DR Reaktivität: Human FACS, IF, WB, IHC (f) Wirt: Maus Monoclonal rHLA-Pan-3475 unconjugated Recombinant Antibody
Produktnummer ABIN6937398
  • Target Alle MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR) Produkte
    MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 21
    • 1
    Human
    Wirt
    • 19
    • 2
    Maus
    Klonalität
    • 21
    Monoklonal
    Konjugat
    • 11
    • 4
    • 2
    • 2
    • 1
    • 1
    Dieser MHC Class II HLA-DP/DQ/DR Antikörper ist unkonjugiert
    Applikation
    • 19
    • 7
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response.
    Kreuzreaktivität (Details)
    Human.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Non-T, non-B human acute lymphoblastic leukemia REH6 cells
    Klon
    RHLA-Pan-3475
    Isotyp
    IgG1 kappa
  • Applikationshinweise

    Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Positive_Control: Raji cells. Human tonsil or lymph node.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
    Andere Bezeichnung
    HLA-DP, HLA-DQ, HLA-DR (HLA-DP/DQ/DR Produkte)
    Hintergrund
    HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5,HLA-Pan (MHC II)
    Cellular localisation: Cell Surface
    Molekulargewicht
    33-35kDa
    UniProt
    P01908, P01909
    Pathways
    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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