IGHG4 Antikörper

Produktnummer ABIN6937504

Produktdetails anti-IGHG4 Antikörper

Target: IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGHG4 Antikörper ist unkonjugiert

Applikation: Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human IGHG4 fragment

Klon: IGHG4-1345

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: Tonsil.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu IGHG4

Target: IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))

Andere Bezeichnung: IGHG4 (IGHG4 Produkte)

Synonyme: immunoglobulin heavy constant gamma 4 (G4m marker) antikoerper, IGHG4 antikoerper

Hintergrund: Ig gamma 4 chain C region, IGHG4, Immunoglobulin heavy constant gamma 4 (G4m marker),IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker)
Cellular localisation: Cytoplasmic

Molekulargewicht: 150kDa

Gen-ID: 3503, 510635

UniProt: P01861