MAML3 Antikörper
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- Target Alle MAML3 Antikörper anzeigen
- MAML3 (Mastermind-Like 3 (MAML3))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser MAML3 Antikörper ist unkonjugiert
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Applikation
- Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human MAML3 protein fragment
- Klon
- MAML3-1303
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product MAML3 Primärantikörper
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- Applikationshinweise
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: MCF-7 cells. Pancreas or Placenta. Cervix or Colon Carcinoma.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- MAML3 (Mastermind-Like 3 (MAML3))
- Andere Bezeichnung
- MAML3 (MAML3 Produkte)
- Synonyme
- AV234550 antikoerper, BC049812 antikoerper, Mam-2 antikoerper, mKIAA1816 antikoerper, Glrp1 antikoerper, CAGH3 antikoerper, ERDA3 antikoerper, GDN antikoerper, MAM-2 antikoerper, MAM2 antikoerper, TNRC3 antikoerper, mastermind like 3 (Drosophila) antikoerper, mastermind-like transcriptional coactivator 3 antikoerper, mastermind like transcriptional coactivator 3 antikoerper, Maml3 antikoerper, MAML3 antikoerper
- Hintergrund
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CAGH3, ERDA3, GDN, MAML3, Mastermind-like protein 3, TNRC3,MAML3 (Mastermind Like Transcriptional Coactivator 3)
Cellular localisation: Cytoplasmic - Molekulargewicht
- 150-170kDa
- Gen-ID
- 55534, 586165
- UniProt
- Q96JK9
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