MTAP Antikörper (AA 97-196)
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- Target Alle MTAP Antikörper anzeigen
- MTAP (Methylthioadenosine phosphorylase (MTAP))
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Bindungsspezifität
- AA 97-196
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser MTAP Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)
- Klon
- MTAP-1813
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product MTAP Primärantikörper
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- Applikationshinweise
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Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HepG2, A431, HeLa, HAP1 or MCF-7 cells. Kidney.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- MTAP (Methylthioadenosine phosphorylase (MTAP))
- Andere Bezeichnung
- MTAP (MTAP Produkte)
- Synonyme
- BDMF antikoerper, DMSFH antikoerper, DMSMFH antikoerper, LGMBF antikoerper, MSAP antikoerper, c86fus antikoerper, Cc1-6 antikoerper, 1300019I21Rik antikoerper, MTAPase antikoerper, zgc:66012 antikoerper, mtap antikoerper, methylthioadenosine phosphorylase antikoerper, 5'-methylthioadenosine phosphorylase antikoerper, 6-oxopurine nucleoside phosphorylase antikoerper, methylthioadenosine phosphorylase L homeolog antikoerper, MTAP antikoerper, Mtap antikoerper, mtaP antikoerper, MMAH_RS04260 antikoerper, TAGG_RS05050 antikoerper, Toce_0364 antikoerper, VDIS_RS03165 antikoerper, MFER_RS02485 antikoerper, Intca_0886 antikoerper, DESMU_RS05370 antikoerper, Dester_1490 antikoerper, ARCVE_RS05445 antikoerper, Mahau_1873 antikoerper, MZHIL_RS01440 antikoerper, mtap antikoerper, mtap.L antikoerper
- Hintergrund
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BDMF, DMSFH, DMSMFH, Epididymis luminal protein 249, HEL249, LGMBF, MeSAdo phosphorylase, Methylthioadenosine phosphorylase, MSAP, MTA phosphorylase, MTAP, MTAPase, S-methyl-5''-thioadenosine phosphorylase,MTAP (Tumor Suppressor Marker)
Cellular localisation: Cytoplasmic - Molekulargewicht
- 31kDa
- Gen-ID
- 4507, 193268
- UniProt
- Q13126
- Pathways
- Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process
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