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MUC4 Antikörper (AA 1730-1864)

MUC4 Reaktivität: Human IHC (f) Wirt: Maus Monoclonal MUC4-3105 unconjugated
Produktnummer ABIN6937955
  • Target Alle MUC4 Antikörper anzeigen
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Bindungsspezifität
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1730-1864
    Reaktivität
    • 37
    • 13
    • 3
    Human
    Wirt
    • 30
    • 8
    Maus
    Klonalität
    • 22
    • 16
    Monoklonal
    Konjugat
    • 22
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser MUC4 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.
    Kreuzreaktivität (Details)
    Human.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)
    Klon
    MUC4-3105
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product MUC4 Primärantikörper
  • Applikationshinweise

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Stomach, Colon or esophagus.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Andere Bezeichnung
    MUC4 (MUC4 Produkte)
    Synonyme
    4933405I11Rik antikoerper, Asgp antikoerper, ASGP antikoerper, HSA276359 antikoerper, MUC-4 antikoerper, ASGP-1 antikoerper, Psmc antikoerper, mucin 4 antikoerper, mucin 4, cell surface associated antikoerper, Muc4 antikoerper, MUC4 antikoerper
    Hintergrund
    Ascites sialoglycoprotein 1, Ascites sialoglycoprotein 2, Ascites sialoglycoprotein, ASGP, ASGP-1, ASGP-2, Mucin 4 cell surface associated, Mucin-4 beta chain, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin,MUC4 (Mucin 4 / Gastric Mucin)
    Cellular localisation: Cytoplasmic
    Molekulargewicht
    235kDa
    Gen-ID
    4585, 369646
    UniProt
    Q99102
    Pathways
    Regulation of Leukocyte Mediated Immunity
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