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PPP3R1 Antikörper

PPP3R1 Reaktivität: Human IHC (f) Wirt: Maus Monoclonal CALNB-2342 unconjugated
Produktnummer ABIN6938230
  • Target Alle PPP3R1 Antikörper anzeigen
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Reaktivität
    • 28
    • 14
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 22
    • 6
    Maus
    Klonalität
    • 22
    • 6
    Monoklonal
    Konjugat
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PPP3R1 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 12
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
    Kreuzreaktivität (Details)
    Human.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length Calcineurin B protein
    Klon
    CALNB-2342
    Isotyp
    IgG1 kappa
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  • Applikationshinweise

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Andere Bezeichnung
    PPP3R1 (PPP3R1 Produkte)
    Synonyme
    si:ch211-274c22.8 antikoerper, canb antikoerper, CALNB1 antikoerper, CNB antikoerper, CNB1 antikoerper, CaNB1 antikoerper, Cnb1 antikoerper, MCIP1 antikoerper, protein phosphatase 3, regulatory subunit B, alpha a antikoerper, protein phosphatase 3 regulatory subunit B, alpha S homeolog antikoerper, protein phosphatase 3 regulatory subunit B, alpha antikoerper, protein phosphatase 3, regulatory subunit B, alpha antikoerper, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) antikoerper, ppp3r1a antikoerper, ppp3r1.S antikoerper, PPP3R1 antikoerper, Ppp3r1 antikoerper
    Hintergrund
    Calcineurin B, type I (19 kDa), Calcineurin subunit B type 1, CALNB1, CNB1, PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform, Protein phosphatase 3 regulatory subunit B alpha, Protein phosphatase 3 regulatory subunit B alpha isoform 1,Calcineurin B / PPP3R1
    Cellular localisation: Cytoplasmic and Cell Surface
    Molekulargewicht
    19kDa
    Gen-ID
    5534, 280604
    UniProt
    P63098
    Pathways
    RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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