Rekombinanter SOX2 Antikörper (AA 176-305)
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- Target Alle SOX2 Antikörper anzeigen
- SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
- Antikörpertyp
- Recombinant Antibody
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Bindungsspezifität
- AA 176-305
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser SOX2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.
- Kreuzreaktivität (Details)
- Human. Mouse. Dog
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment (within aa176-305) of human SOX2 protein (exact sequence is proprietary)
- Klon
- SOX2-3169R
- Isotyp
- IgG
- Top Product
- Discover our top product SOX2 Primärantikörper
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- Applikationshinweise
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Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: A549, NCCIT cells. Lung or Cervical carcinoma.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
- Andere Bezeichnung
- SOX2 (SOX2 Produkte)
- Synonyme
- ANOP3 antikoerper, MCOPS3 antikoerper, RGD1565646 antikoerper, Sox-2 antikoerper, lcc antikoerper, ysb antikoerper, cb236 antikoerper, wu:fb83g04 antikoerper, wu:fc14d07 antikoerper, zgc:65860 antikoerper, zgc:77389 antikoerper, SRY-box2 antikoerper, Xsox-2 antikoerper, anop3 antikoerper, mcops3 antikoerper, sox-2 antikoerper, SRY-box 2 antikoerper, SRY box 2 antikoerper, SRY (sex determining region Y)-box 2 antikoerper, SRY-box 2 S homeolog antikoerper, SOX2 antikoerper, Sox2 antikoerper, sox2 antikoerper, sox2.S antikoerper
- Hintergrund
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ANOP3, Delta EF2a, MCOPS3 (Microphthalmia Syndromic type 3), SOX-2, SRY (sex determining region Y) box 2, SRY related HMG box 2, Transcription factor SOX-2, ysb,SOX2 (Embryonic Stem Cell Marker)
Cellular localisation: Nuclear - Molekulargewicht
- 34kDa
- Gen-ID
- 6657, 518438
- UniProt
- P48431
- Pathways
- Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis
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