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Spectrin beta Chain, Erythrocyte (SPTB) Antikörper

SPTB Reaktivität: Human WB, IF, IHC, Coat, ELISA, IHC (f) Wirt: Maus Monoclonal RG-26 unconjugated
Produktnummer ABIN6938442
  • Target Alle Spectrin beta Chain, Erythrocyte (SPTB) Antikörper anzeigen
    Spectrin beta Chain, Erythrocyte (SPTB)
    Reaktivität
    • 11
    • 1
    • 1
    Human
    Wirt
    • 7
    • 4
    Maus
    Klonalität
    • 7
    • 4
    Monoklonal
    Konjugat
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Unkonjugiert
    Applikation
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Coating (Coat), ELISA, Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.
    Kreuzreaktivität (Details)
    Human. Mouse. Rat.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Red cell membranes
    Klon
    RG-26
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product SPTB Primärantikörper
  • Applikationshinweise

    Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL), ,Immunofluorescence (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Jurkat whole cell lysate (WB). Human colon carcinoma tissue (IHC).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    Spectrin beta Chain, Erythrocyte (SPTB)
    Andere Bezeichnung
    SPTB (SPTB Produkte)
    Synonyme
    AI842465 antikoerper, D330027P03Rik antikoerper, Gm1301 antikoerper, Spnb-1 antikoerper, Spnb1 antikoerper, ja antikoerper, jaundiced antikoerper, mKIAA4219 antikoerper, EL3 antikoerper, HS2 antikoerper, HSPTB1 antikoerper, SPH2 antikoerper, spectrin beta, erythrocytic antikoerper, spectrin, beta, erythrocytic antikoerper, SPTB antikoerper, Sptb antikoerper
    Hintergrund
    Beta-I spectrin, EL3, erythrocyte, HS2, SPTB1, HSPTB1, membrane cytoskeletal protein, spectrin beta (erythrocytic),Spectrin beta I (SPTB)
    Cellular localisation: Cell Surface
    Molekulargewicht
    246kDa
    Gen-ID
    6710, 26915
    UniProt
    O15020
    Pathways
    Regulation of Actin Filament Polymerization
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