SREBF2 Antikörper
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- Target Alle SREBF2 Antikörper anzeigen
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser SREBF2 Antikörper ist unkonjugiert
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Applikation
- ELISA, Coating (Coat)
- Spezifität
- The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human SREBF2 protein
- Klon
- SREBP2-1579
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product SREBF2 Primärantikörper
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- Applikationshinweise
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Known_Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: Ubiqutious expression in adult and fetal tissues. Hep2 or HeLa cells.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
- Andere Bezeichnung
- SREBF2 (SREBF2 Produkte)
- Synonyme
- SREBF2 antikoerper, srebp2 antikoerper, SREBP2 antikoerper, zgc:158371 antikoerper, AI608257 antikoerper, SREBP-2 antikoerper, SREBP2gc antikoerper, bHLHd2 antikoerper, lop13 antikoerper, nuc antikoerper, Srebf2_retired antikoerper, sterol regulatory element binding transcription factor 2 antikoerper, sterol regulatory element binding factor 2 antikoerper, sterol regulatory element binding transcription factor 2 L homeolog antikoerper, SREBF2 antikoerper, srebf2 antikoerper, Srebf2 antikoerper, srebf2.L antikoerper
- Hintergrund
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AI608257, bHLHd2, Class D basic helix-loop-helix protein 2, OTTHUMP00000028740, Processed sterol regulatory element-binding protein 2, SRBP2_HUMAN, SREBF 2, Srebf2, SREBF2 protein, SREBP 2, SREBP2, SREBP2gc, sterol regulatory element binding factor 2, Sterol regulatory element binding transcription factor 2,SREBP2
Cellular localisation: Nuclear and Cytoplasmic. - Molekulargewicht
- 68/125kDa
- Gen-ID
- 6721, 443258
- UniProt
- Q12772
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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