STAR Antikörper (AA 39-108)
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- Target Alle STAR Antikörper anzeigen
- STAR (Steroidogenic Acute Regulatory Protein (STAR))
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Bindungsspezifität
- AA 39-108
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser STAR Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone.It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment (around aa 39-108) of human STAR protein (exact sequence is proprietary)
- Klon
- STAR-2140
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product STAR Primärantikörper
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- Applikationshinweise
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: K-562 cells. Adrenal or Testicular Carcinoma.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- STAR (Steroidogenic Acute Regulatory Protein (STAR))
- Andere Bezeichnung
- STAR (STAR Produkte)
- Synonyme
- STARD1 antikoerper, AV363654 antikoerper, D8Ertd419e antikoerper, star antikoerper, LOC100219165 antikoerper, StARD1 antikoerper, steroidogenic acute regulatory protein antikoerper, steroidogenic acute regulatory protein L homeolog antikoerper, STAR antikoerper, Star antikoerper, star antikoerper, star.L antikoerper
- Hintergrund
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Cholesterol trafficker, Luteinizing hormone induced protein, Mitochondrial steroid acute regulatory protein, StAR, StAR related lipid transfer (START) domain containing 1, StARD1, START domain-containing protein 1, Steroid acute regulatory protein, Steroidogenic acute regulator (STAR), Steroidogenic acute regulatory protein mitochondrial,StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker)
Cellular localisation: Cytoplasmic (Mitochondria) - Molekulargewicht
- 30kDa
- Gen-ID
- 6770, 521535
- UniProt
- P49675
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis
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