Cadherin-16 Antikörper (AA 371-507)

Produktnummer ABIN6939023

Produktdetails anti-Cadherin-16 Antikörper

Target: Cadherin-16 (CDH16)

Bindungsspezifität: AA 371-507

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cadherin-16 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Coating (Coat)

Spezifität: This MAb recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Kreuzreaktivität (Details): Human,

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 371-507) of human CDH16 protein (exact sequence is proprietary)

Klon: CDH16-2448

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Positive Control: Normal kidney or renal cell carcinoma.

Known Application: ELISA (For coating, order Ab without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

Haltbarkeit: 24 months

Details zu Cadherin-16

Target: Cadherin-16 (CDH16)

Andere Bezeichnung: CDH16 (CDH16 Produkte)

Synonyme: cadherin 16 antikoerper, CDH16 antikoerper, Cdh16 antikoerper

Hintergrund: Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody,Ksp-Cadherin / CDH16 (Renal Cell Marker)
Cellular localisation: Cell Surface and Cytoplasmic

Molekulargewicht: 130kDa

Gen-ID: 1014, 513660

UniProt: O75309