MERTK Antikörper (AA 55-148)

Produktnummer ABIN6939061

Produktdetails anti-MERTK Antikörper

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Bindungsspezifität: AA 55-148

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MERTK Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

Kreuzreaktivität (Details): Human,

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human MERTK protein fragment (around aa 55-148) (exact sequence is proprietary)

Klon: MERTK-3015

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human colon tissue (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

Haltbarkeit: 24 months

Details zu MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Andere Bezeichnung: MERTK (MERTK Produkte)

Synonyme: MER antikoerper, RP38 antikoerper, c-mer antikoerper, Eyk antikoerper, Mer antikoerper, Nyk antikoerper, nmf12 antikoerper, rdy antikoerper, C-EYK antikoerper, MERTK antikoerper, DKFZp469D2215 antikoerper, si:ch1073-268l12.2 antikoerper, MER proto-oncogene, tyrosine kinase antikoerper, c-mer proto-oncogene tyrosine kinase antikoerper, c-mer proto-oncogene tyrosine kinase a antikoerper, MERTK antikoerper, Mertk antikoerper, mertka antikoerper

Hintergrund: CEyk, MER receptor tyrosine kinase, MERK, MERPEN, nmf12, Nyk, Proto-oncogene c-Mer, RP38, STK kinase,MerTK (Innate Immune Checkpoint)
Cellular localisation: Cell surface.

Molekulargewicht: 110kDa

Gen-ID: 10461, 306178

UniProt: Q12866

Pathways: RTK Signalweg