Chromogranin A Antikörper

Produktnummer ABIN6939126

Produktdetails anti-Chromogranin A Antikörper

Target: Chromogranin A (CHGA)

Reaktivität: Human, Ratte, Maus, Affe, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Chromogranin A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Spezifität: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Keine Kreuzreaktivität: Meerschweinchen, Kaninchen, Schaf

Aufreinigung: Purified by Protein A/G

Immunogen: Human pheochromocytoma

Klon: LK2H10

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: PC12 cells. Adrenal gland, bowel, thyroid, pancreas or pheochromocytoma.

Known Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Chromogranin A

Target: Chromogranin A (CHGA)

Andere Bezeichnung: CHGA (CHGA Produkte)

Synonyme: CGA antikoerper, CG-ALPHA antikoerper, FSHA antikoerper, GPHA1 antikoerper, GPHa antikoerper, HCG antikoerper, LHA antikoerper, TSHA antikoerper, ChrA antikoerper, fj05f09 antikoerper, si:dkey-177p2.2 antikoerper, wu:fj05f09 antikoerper, zgc:101749 antikoerper, zgc:56075 antikoerper, CHGA antikoerper, cgA antikoerper, chga antikoerper, chromogranin A antikoerper, glycoprotein hormones, alpha polypeptide antikoerper, uncharacterized CHGA antikoerper, chromogranin A S homeolog antikoerper, CHGA antikoerper, CGA antikoerper, Chga antikoerper, chga antikoerper, chga.S antikoerper

Molekulargewicht: 68-75kDa

Gen-ID: 1113

UniProt: P10645

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling