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DMC1 Antikörper

DMC1 Reaktivität: Human, Maus, Ratte, Rind (Kuh) WB, IHC, IF, StM Wirt: Maus Monoclonal 2H12-4 unconjugated
Produktnummer ABIN6939141
  • Target Alle DMC1 Antikörper anzeigen
    DMC1 (DNA Meiotic Recombinase 1 (DMC1))
    Reaktivität
    • 56
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh)
    Wirt
    • 49
    • 7
    Maus
    Klonalität
    • 50
    • 6
    Monoklonal
    Konjugat
    • 28
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DMC1 Antikörper ist unkonjugiert
    Applikation
    • 49
    • 29
    • 20
    • 14
    • 13
    • 13
    • 9
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Staining Methods (StM)
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human DMC1 protein.
    Klon
    2H12-4
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product DMC1 Primärantikörper
  • Applikationshinweise

    Positive Control: HeLa cells. Cervix or prostate.

    Known Application: Immunofluorescence (0.5-1 μg/mL), Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    DMC1 (DNA Meiotic Recombinase 1 (DMC1))
    Andere Bezeichnung
    DMC1 (DMC1 Produkte)
    Synonyme
    DMC1 antikoerper, zgc:136628 antikoerper, Dmc1h antikoerper, Lim15 antikoerper, Mei11 antikoerper, sgdp antikoerper, DCM1 antikoerper, DMC1H antikoerper, LIM15 antikoerper, dJ199H16.1 antikoerper, DNA meiotic recombinase 1 antikoerper, DMC1 antikoerper, dmc1 antikoerper, Dmc1 antikoerper
    Hintergrund
    DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the doublestrand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.
    Molekulargewicht
    37kDa
    Gen-ID
    11144
    UniProt
    Q14565
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