Cathepsin D Antikörper (AA 104-250)

Produktnummer ABIN6939214

Produktdetails anti-Cathepsin D Antikörper

Target: Cathepsin D (CTSD)

Bindungsspezifität: AA 104-250

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cathepsin D Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human Cathepsin D protein (around aa 104-250) (exact sequence is proprietary)

Klon: CTSD-2781

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: K-562, A431 or SK-BR3 cells. Kidney, Liver, Lung or Breast.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Cathepsin D

Target: Cathepsin D (CTSD)

Andere Bezeichnung: CTSD (CTSD Produkte)

Synonyme: catD antikoerper, fb93e11 antikoerper, fj17b09 antikoerper, wu:fb93e11 antikoerper, wu:fj17b09 antikoerper, LOC398557 antikoerper, Cathd antikoerper, CatD antikoerper, LOC100136761 antikoerper, CTSD antikoerper, DKFZp469J0315 antikoerper, DDBDRAFT_0205785 antikoerper, DDBDRAFT_0215012 antikoerper, DDB_0205785 antikoerper, DDB_0215012 antikoerper, CLN10 antikoerper, CPSD antikoerper, CD antikoerper, cathepsin D antikoerper, cathepsin D S homeolog antikoerper, lysosomal aspartic protease antikoerper, cathepsin D-like antikoerper, ctsd antikoerper, LOC398557 antikoerper, ctsd.S antikoerper, CatD antikoerper, LOC5567565 antikoerper, LOC100136761 antikoerper, CTSD antikoerper, Cathd antikoerper, ctsD antikoerper, catd antikoerper, Ctsd antikoerper, LOC443060 antikoerper

Hintergrund: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Molekulargewicht: 46kDa (Procathepsin D), 28kDa (Cathepsin D)

Gen-ID: 1509

UniProt: P07339

Pathways: Peptide Hormone Metabolism