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EGFR Antikörper (AA 344-492)

Name: EGFR Antikörper (AA 344-492)
Brand: antibodies-online
SKU: ABIN6939284
Price: 663.89 EUR
Availability: InStock

EGFR Reaktivität: Human IHC, StM Wirt: Maus Monoclonal GFR-2341 unconjugated

Western Blot Analysis of A431 cell lysate using EGFR Mouse Monoclonal Antibody (GFR/2341). (EGFR Antikörper (AA 344-492))

Analysis of Protein Array containing more than 19,000 full-length human proteins using EGFR Mouse Monoclonal Antibody (GFR/2341) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. (EGFR Antikörper (AA 344-492))

PAr

Formalin-fixed, paraffin-embedded human Lung SqCC stained with EGFR Mouse Monoclonal Antibody (GFR/2341). (EGFR Antikörper (AA 344-492))

IHC

Formalin-fixed, paraffin-embedded human Placenta stained with EGFR Mouse Monoclonal Antibody (GFR/2341). (EGFR Antikörper (AA 344-492))

IHC

SDS-PAGE Analysis Purified EGFR Mouse Monoclonal Antibody (GFR/2341). (EGFR Antikörper (AA 344-492))

SDS

5 Abbildungen

Produktnummer ABIN6939284

Datenblatt (PDF)

Target Alle EGFR Antikörper anzeigen

EGFR (Epidermal Growth Factor Receptor (EGFR))
Bindungsspezifität
40

39

31

30

30

28

27

26

21

21

21

16

16

16

15

15

15

15

11

11

10

10

9

9

8

8

7

6

5

5

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3

3
AA 344-492
Reaktivität
756

296

287

26

26

24

20

14

8

3

2

2

1

1

1

1

1

1
Human
Wirt
581

176

14

13

5

1

1
Maus
Passende Sekundärantikörper
Klonalität
535

251

2
Monoklonal
Konjugat
416

58

29

22

20

17

17

16

15

15

15

12

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

2

1

1

1

1

1

1
Dieser EGFR Antikörper ist unkonjugiert
Applikation
540

248

152

151

131

102

102

95

82

49

37

35

34

19

11

7

5

4

4

3

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Immunohistochemistry (IHC), Staining Methods (StM)

Spezifität

This MAb recognizes a protein of 170 kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Aufreinigung

Purified by Protein A/G

Immunogen

Recombinant fragment of human EGFR protein (around aa 344-492) (exact sequence is proprietary)

Klon

GFR-2341

Isotyp

IgG2b kappa

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Applikationshinweise

Positive Control: A431 cells. Placenta, Breast, Colon or Bladder cancer.
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

200 μg/mL

Buffer

10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-80 °C

Informationen zur Lagerung

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit

24 months
Target

EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung

EGFR (EGFR Produkte)

Molekulargewicht

~170kDa (wild type) and ~145kDa (vIII variant)

Gen-ID

1956

UniProt

P00533

Pathways

NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine