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EGFR Antikörper (Extracellular Domain)

Name: EGFR Antikörper (Extracellular Domain)
Brand: antibodies-online
SKU: ABIN6939288
Price: 663.89 EUR
Availability: InStock

EGFR Reaktivität: Human IF, FACS Wirt: Maus Monoclonal GFR450 unconjugated

Confocal Immunofluorescent analysis of A431 cells using AF488-labeled EGFR Monoclonal Antibody (GFR450) (Green). (EGFR Antikörper (Extracellular Domain))

SDS-PAGE Analysis Purified EGFR Mouse Monoclonal Antibody (GFR/450). (EGFR Antikörper (Extracellular Domain))

SDS

Analysis of Protein Array containing more than 19,000 full-length human proteins using EGFR Mouse Monoclonal Antibody (GFR/450) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. (EGFR Antikörper (Extracellular Domain))

PAr

Confocal Immunofluorescent analysis of A431 cells using AF488-labeled Isotype Control MAb (IgG2a) (Green). (EGFR Antikörper (Extracellular Domain))

Flow Cytometry of human EGFR on A431 cells. (EGFR Antikörper (Extracellular Domain))

FACS

5 Abbildungen

Produktnummer ABIN6939288

Datenblatt (PDF)

Target Alle EGFR Antikörper anzeigen

EGFR (Epidermal Growth Factor Receptor (EGFR))
Bindungsspezifität
40

39

31

30

29

28

27

26

21

21

21

16

16

16

15

15

15

15

11

11

10

10

9

9

8

8

7

6

5

5

5

4

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3

3
Extracellular Domain
Reaktivität
756

296

287

26

26

24

20

14

8

3

2

2

1

1

1

1

1

1
Human
Wirt
581

176

14

13

5

1

1
Maus
Passende Sekundärantikörper
Klonalität
535

251

2
Monoklonal
Konjugat
416

58

29

22

20

17

17

16

15

15

15

12

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

2

1

1

1

1

1

1
Dieser EGFR Antikörper ist unkonjugiert
Applikation
540

248

152

151

130

102

102

95

82

49

37

35

34

19

11

7

6

4

4

3

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Immunofluorescence (IF), Flow Cytometry (FACS)

Spezifität

This MAb recognizes a protein of 170 kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Keine Kreuzreaktivität

Maus

Aufreinigung

Purified by Protein A/G

Immunogen

Recombinant extracellular domain of human EGFR protein

Klon

GFR450

Isotyp

IgG2a kappa

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Applikationshinweise

Positive Control: A431 cells, Breast or Bladder cancer.
Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

200 μg/mL

Buffer

10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-80 °C

Informationen zur Lagerung

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit

24 months
Target

EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung

EGFR (EGFR Produkte)

Molekulargewicht

~170kDa (wild type) and ~145kDa (vIII variant)

Gen-ID

1956

UniProt

P00533

Pathways

NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine