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ErbB2/Her2 Antikörper (AA 311-462)

ErbB2/Her2 Reaktivität: Human IHC, StM Wirt: Maus Monoclonal ERBB2-2452 unconjugated
Produktnummer ABIN6939316
  • Target Alle ErbB2/Her2 Antikörper anzeigen
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Bindungsspezifität
    • 31
    • 29
    • 29
    • 29
    • 26
    • 26
    • 22
    • 22
    • 16
    • 15
    • 13
    • 13
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    AA 311-462
    Reaktivität
    • 518
    • 188
    • 166
    • 32
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 410
    • 154
    • 10
    • 5
    • 3
    • 3
    Maus
    Klonalität
    • 416
    • 166
    • 2
    Monoklonal
    Konjugat
    • 268
    • 45
    • 37
    • 28
    • 23
    • 22
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Dieser ErbB2/Her2 Antikörper ist unkonjugiert
    Applikation
    • 297
    • 229
    • 139
    • 98
    • 93
    • 93
    • 91
    • 80
    • 61
    • 51
    • 30
    • 21
    • 12
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    Recognizes a protein of 185 kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant human HER-2 protein fragment (around aa 311-462) (exact sequence is proprietary)
    Klon
    ERBB2-2452
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product ErbB2/Her2 Primärantikörper
  • Applikationshinweise

    Positive Control: SKBR-3 cells. Breast Cancers.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Andere Bezeichnung
    ERBB2 (ErbB2/Her2 Produkte)
    Synonyme
    CD340 antikoerper, HER-2 antikoerper, HER-2/neu antikoerper, HER2 antikoerper, MLN 19 antikoerper, NEU antikoerper, NGL antikoerper, TKR1 antikoerper, Erbb-2 antikoerper, Neu antikoerper, c-erbB2 antikoerper, c-neu antikoerper, mKIAA3023 antikoerper, wu:fv70f10 antikoerper, zgc:63601 antikoerper, erb2 antikoerper, erb-b2 receptor tyrosine kinase 2 antikoerper, ERBB2 antikoerper, Erbb2 antikoerper, erbb2 antikoerper
    Molekulargewicht
    185kDa
    Gen-ID
    2064
    UniProt
    P04626
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development
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