Estrogen Receptor alpha Antikörper (AA 129-312)

Produktnummer ABIN6939347

Produktdetails anti-Estrogen Receptor alpha Antikörper

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Bindungsspezifität: AA 129-312

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Staining Methods (StM)

Spezifität: This monoclonal antibody is specific to estrogen receptor alpha (ER alpha) and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant human ESR1 protein fragment (around aa129-312) (exact sequence is proprietary)

Klon: ESR1-3559

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: MCF-7 cells. Breast or Endometrial Carcinoma (IHC).

Known Application: Flow Cytometry (1-2 μg/million cells),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: ESR1 (ESR1 Produkte)

Synonyme: LOC398734 antikoerper, AA420328 antikoerper, AU041214 antikoerper, ER-alpha antikoerper, ER[a] antikoerper, ERa antikoerper, ERalpha antikoerper, ESR antikoerper, Estr antikoerper, Estra antikoerper, Nr3a1 antikoerper, NR3A1 antikoerper, eralpha antikoerper, zfER[a] antikoerper, ER antikoerper, ESRA antikoerper, ESTRR antikoerper, Era antikoerper, akap12 antikoerper, cb27 antikoerper, esr1 antikoerper, fb72g12 antikoerper, id:ibd1202 antikoerper, sb:cb27 antikoerper, si:ch73-192g21.1 antikoerper, wu:fb72g12 antikoerper, wu:fc21c03 antikoerper, Esr antikoerper, RNESTROR antikoerper, ERALPHA antikoerper, er antikoerper, esr antikoerper, nr3a1 antikoerper, XER antikoerper, era antikoerper, esra antikoerper, ERbeta antikoerper, xesr-1 antikoerper, xlERalpha1 antikoerper, xlERalpha2 antikoerper, ESR1 antikoerper, estrogen receptor 1 L homeolog antikoerper, estrogen receptor 1 (alpha) antikoerper, estrogen receptor 1 antikoerper, A kinase (PRKA) anchor protein 12b antikoerper, esr1.L antikoerper, Esr1 antikoerper, ESR1 antikoerper, esr1 antikoerper, akap12b antikoerper

Molekulargewicht: ~67kDa

Gen-ID: 2099

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly