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FAT1 Antikörper (Cytoplasmic Domain)

FAT1 Reaktivität: Drosophila melanogaster ELISA, WB, Coat, IF Wirt: Maus Monoclonal FAT1-3D7-1 unconjugated
Produktnummer ABIN6939370
  • Target Alle FAT1 Antikörper anzeigen
    FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))
    Bindungsspezifität
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Domain
    Reaktivität
    • 17
    • 1
    • 1
    Drosophila melanogaster
    Wirt
    • 15
    • 2
    Maus
    Klonalität
    • 15
    • 2
    Monoklonal
    Konjugat
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FAT1 Antikörper ist unkonjugiert
    Applikation
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Coating (Coat), Immunofluorescence (IF)
    Kreuzreaktivität (Details)
    Expected to cross-react with Chimpanzee. Rat (92 % . 85 % identity with immunogen. respectively) due to sequence homology.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Cytoplasmic domain of Drosophila Fat protein.
    Klon
    FAT1-3D7-1
    Isotyp
    IgM kappa
    Top Product
    Discover our top product FAT1 Primärantikörper
  • Applikationshinweise

    Positive Control: Wild type imaginal discs from third instar Drosophila larvae.

    Known Application: ELISA (For coating, order antibody without BSA), Western Blot (0.5-1.0 μg/mL), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))
    Andere Bezeichnung
    FAT1 (FAT1 Produkte)
    Synonyme
    CDHF7 antikoerper, CDHR8 antikoerper, FAT antikoerper, ME5 antikoerper, hFat1 antikoerper, Fath antikoerper, mFat1 antikoerper, AU023433 antikoerper, 2310038E12Rik antikoerper, FAT1 antikoerper, FAT atypical cadherin 1 antikoerper, FAT tumor suppressor homolog 1 (Drosophila) antikoerper, protocadherin Fat 1 antikoerper, FAT1 antikoerper, Fat1 antikoerper, LOC100175143 antikoerper, fat1 antikoerper
    Hintergrund
    The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychic disorders, and its action may be of patho-physiological importance.
    Molekulargewicht
    500kDa
    Gen-ID
    2195
    UniProt
    Q14517
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