SERBP1 Antikörper (AA 3-139)

Produktnummer ABIN6939487

Produktdetails anti-SERBP1 Antikörper

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Bindungsspezifität: AA 3-139

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SERBP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human SERBP1 protein (around aa3-139) (exact sequence is proprietary)

Klon: SERBP1-3493

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human kidney or bladder tissue (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu SERBP1

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Andere Bezeichnung: SERBP1 (SERBP1 Produkte)

Synonyme: CHD3IP antikoerper, HABP4L antikoerper, PAI-RBP1 antikoerper, PAIRBP1 antikoerper, 1200009K13Rik antikoerper, 9330147J08Rik antikoerper, AL022786 antikoerper, Pairbp1 antikoerper, Pai-Rbp1 antikoerper, Rda288 antikoerper, cgi-55 antikoerper, chd3ip antikoerper, habp4l antikoerper, pai-rbp1 antikoerper, pairbp1 antikoerper, rda288 antikoerper, hm:zeh0245 antikoerper, serbp1 antikoerper, wu:fa12d05 antikoerper, wu:fb36e07 antikoerper, wu:fc16f12 antikoerper, wu:fj13e12 antikoerper, zgc:55489 antikoerper, SERPINE1 mRNA binding protein 1 antikoerper, serpine1 mRNA binding protein 1 antikoerper, Serpine1 mRNA binding protein 1 antikoerper, SERPINE1 mRNA binding protein 1 L homeolog antikoerper, SERPINE1 mRNA binding protein 1a antikoerper, SERBP1 antikoerper, Serbp1 antikoerper, serbp1.L antikoerper, serbp1a antikoerper

Hintergrund: PAI-RBP1 (plasminogen activator inhibitor 1 RNA-binding protein), also known as SERBP1 (SERPINE1 mRNA-binding protein 1), CGI-55, CHD3IP (chromodomain helicase DNA binding protein 3 interacting protein), HABP4L or PAI-RBP1, is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. PAI-RBP1 is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, PAI-RBP1 interacts with Mi2- and may be involved in chromatin remodeling. PAI-RBP1 also interacts with PGRMC1 and participates in the transduction of Progesterone's antiapoptotic action in ovarian cell types. The gene encoding PAI-RBP1 is overexpressed in ovarian cancer, suggesting a possible role for PAI-RBP1 in tumorigenesis and tumor metastasis.

Molekulargewicht: 60kDa

Gen-ID: 26135

UniProt: Q8NC51