GP2 Antikörper (AA 35-179)

Produktnummer ABIN6939543

Produktdetails anti-GP2 Antikörper

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Bindungsspezifität: AA 35-179

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GP2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Coating (Coat), Staining Methods (StM)

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human GP2 protein (around aa 35-179) (exact sequence is proprietary)

Klon: GP2-1803

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: PANC-1 cells. Pancreas.

Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu GP2

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Andere Bezeichnung: GP2 (GP2 Produkte)

Synonyme: ZAP75 antikoerper, 2310037I18Rik antikoerper, AV060639 antikoerper, gp80 antikoerper, glycoprotein 2 antikoerper, glycoprotein 2 (zymogen granule membrane) antikoerper, GP2 antikoerper, Gp2 antikoerper

Substanzklasse: Viral Protein

Hintergrund: GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

Molekulargewicht: 59kDa

Gen-ID: 2813

UniProt: P55259