HLA-DRA Antikörper

Produktnummer ABIN6939637

Produktdetails anti-HLA-DRA Antikörper

Target: HLA-DRA (HLA Class II DR alpha (HLA-DRA))

Reaktivität: Human, Rind (Kuh), Cat

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HLA-DRA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Aufreinigung: Purified by Protein A/G

Immunogen: Human peripheral blood leukocytes

Klon: 169-1B5-2

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Ramos, Daudi or HuT78 cells. Tonsil or lymph node.

Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu HLA-DRA

Target: HLA-DRA (HLA Class II DR alpha (HLA-DRA))

Andere Bezeichnung: HLA-DRA (HLA-DRA Produkte)

Synonyme: HLA-DRA1 antikoerper, MLRW antikoerper, DR-alpha antikoerper, HLA-DRA antikoerper, Mamu-DRA1 antikoerper, major histocompatibility complex, class II, DR alpha L homeolog antikoerper, major histocompatibility complex, class II, DR alpha antikoerper, hla-dra.L antikoerper, HLA-DRA antikoerper, MAMU-DRA antikoerper, BOLA-DRA antikoerper

Hintergrund: This antibody detects a monomorphic general framework determinant of HLA-DR Class II antigen.It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.

Molekulargewicht: 36kDa (α, chain) and 27kDa (β, chain)

Gen-ID: 3122

UniProt: P01903

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Human Leukocyte Antigen (HLA) in Adaptive Immune Response