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HLA-DRA Antikörper

HLA-DRA Reaktivität: Human IHC, FACS, IF, StM Wirt: Maus Monoclonal 19-26-1-same as MB-26-1 unconjugated
Produktnummer ABIN6939638
  • Target Alle HLA-DRA Antikörper anzeigen
    HLA-DRA (HLA Class II DR alpha (HLA-DRA))
    Reaktivität
    • 85
    • 17
    • 10
    • 10
    • 9
    • 9
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 57
    • 42
    • 2
    • 1
    Maus
    Klonalität
    • 59
    • 43
    Monoklonal
    Konjugat
    • 49
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser HLA-DRA Antikörper ist unkonjugiert
    Applikation
    • 45
    • 44
    • 33
    • 29
    • 16
    • 11
    • 10
    • 9
    • 9
    • 3
    • 3
    • 3
    • 1
    • 1
    Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Staining Methods (StM)
    Spezifität
    This MAb reacts with the HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Raji cells
    Klon
    19-26-1-same as MB-26-1
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product HLA-DRA Primärantikörper
  • Applikationshinweise

    Positive Control: Raji, Ramos, Daudi or HuT78 cells. Tonsil or lymph node.

    Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    HLA-DRA (HLA Class II DR alpha (HLA-DRA))
    Andere Bezeichnung
    HLA-DRA (HLA-DRA Produkte)
    Synonyme
    HLA-DRA1 antikoerper, MLRW antikoerper, DR-alpha antikoerper, HLA-DRA antikoerper, Mamu-DRA1 antikoerper, major histocompatibility complex, class II, DR alpha L homeolog antikoerper, major histocompatibility complex, class II, DR alpha antikoerper, hla-dra.L antikoerper, HLA-DRA antikoerper, MAMU-DRA antikoerper, BOLA-DRA antikoerper
    Molekulargewicht
    36kDa (α, chain) and 27kDa (β, chain)
    Gen-ID
    3122
    UniProt
    P01903
    Pathways
    T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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