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Rekombinanter IGHM Antikörper

IGHM Reaktivität: Human IHC, StM Wirt: Maus Monoclonal rIM373 unconjugated Recombinant Antibody
Produktnummer ABIN6939721
  • Target Alle IGHM Produkte
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 25
    • 1
    • 1
    Human
    Wirt
    • 13
    • 12
    Maus
    Klonalität
    • 16
    • 9
    Monoklonal
    Konjugat
    • 21
    • 1
    • 1
    • 1
    • 1
    Dieser IGHM Antikörper ist unkonjugiert
    Applikation
    • 12
    • 12
    • 11
    • 8
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Heavy chain of human IgM
    Klon
    RIM373
    Isotyp
    IgG1 kappa
  • Applikationshinweise

    Positive Control: 293T, Raji or hPBL cells. Tonsil or Spleen.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Andere Bezeichnung
    IGHM (IGHM Produkte)
    Synonyme
    AI326478 antikoerper, Igh-6 antikoerper, Igh-M antikoerper, Igh6 antikoerper, Igm antikoerper, muH antikoerper, ighm1 antikoerper, wu:fj14a08 antikoerper, zgc:101769 antikoerper, AGM1 antikoerper, MU antikoerper, VH antikoerper, immunoglobulin heavy constant mu antikoerper, Ighm antikoerper, ighm antikoerper, IGHM antikoerper
    Molekulargewicht
    50-75kDa
    Gen-ID
    3507
    UniProt
    P01871, P20769
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