Integrin beta 4 Antikörper

Produktnummer ABIN6939831

Produktdetails anti-Integrin beta 4 Antikörper

Target: Integrin beta 4 (ITGB4)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Blocking Reagent (BR), Binding Studies (Bind)

Spezifität: Recognizes a protein of 205 kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Aufreinigung: Purified by Protein A/G

Immunogen: Human squamous cell carcinoma (UM-SCC1)

Klon: UM-A9

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: A431 cells, squamous cell carcinoma, colon or placenta.

Known Application: Biological Blockade (Partially blocks laminin binding) (Order Ab without Azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Andere Bezeichnung: ITGB4 (ITGB4 Produkte)

Synonyme: AA407042 antikoerper, C230078O20 antikoerper, CD104 antikoerper, integrin subunit beta 4 antikoerper, integrin beta 4 antikoerper, ITGB4 antikoerper, Itgb4 antikoerper

Molekulargewicht: 205kDa

Gen-ID: 3691

UniProt: P16144

Pathways: Integrin Complex