MCM6 Antikörper (AA 228-368)
-
- Target Alle MCM6 Antikörper anzeigen
- MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))
-
Bindungsspezifität
- AA 228-368
-
Reaktivität
- Human
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser MCM6 Antikörper ist unkonjugiert
-
Applikation
- Immunohistochemistry (IHC), Staining Methods (StM)
- Aufreinigung
- Purified by Protein A/G
- Immunogen
- Recombinant fragment (around aa 228-368) of human MCM6 protein (exact sequence is proprietary)
- Klon
- MCM6-2999
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product MCM6 Primärantikörper
-
-
- Applikationshinweise
-
Positive Control: Human skin or squamous cell carcinoma (IHC).
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Haltbarkeit
- 24 months
-
- Target
- MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))
- Andere Bezeichnung
- MCM6 (MCM6 Produkte)
- Hintergrund
- The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.
- Molekulargewicht
- 105kDa
- Gen-ID
- 4175
- UniProt
- Q14566
- Pathways
- DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
-