Ki-67 Antikörper (AA 2293-2478)

Produktnummer ABIN6940052

Produktdetails anti-Ki-67 Antikörper

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Bindungsspezifität: AA 2293-2478

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Ki-67 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Staining Methods (StM)

Spezifität: Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human Ki67 protein (around aa 2293-2478) (exact sequence is proprietary)

Klon: MKI67-2461

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Any actively proliferating cells. Skin, tonsil or lymph node.

Known Application: Western Blot (1-2 μg/mL), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Ki-67

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Andere Bezeichnung: MKI67 (MKI67 Produkte)

Synonyme: MKI67 antikoerper, kia antikoerper, mki67 antikoerper, MGC132156 antikoerper, D630048A14Rik antikoerper, Ki-67 antikoerper, Ki67 antikoerper, KIA antikoerper, MIB-1 antikoerper, marker of proliferation Ki-67 antikoerper, marker of proliferation Ki-67 L homeolog antikoerper, marker of proliferation Ki-67 S homeolog antikoerper, antigen identified by monoclonal antibody Ki 67 antikoerper, antigen identified by monoclonal antibody Ki-67 antikoerper, nucleolar protein interacting with the FHA domain of MKI67 antikoerper, MKI67 antikoerper, mki67 antikoerper, mki67.L antikoerper, mki67.S antikoerper, Mki67 antikoerper, NIFK antikoerper

Molekulargewicht: 345kDa and 395kDa

Gen-ID: 4288

UniProt: P46013

Pathways: Glycosaminoglycan Metabolic Process